BYU Opens as Double-Digit Favorite Over Iowa State

AMES, IA - OCTOBER 25: Quarterback Bear Bachmeier #47 of the BYU Cougars scrsambles to get out of the end zone as defensive back Marcus Neal #31 of the Iowa State Cyclones puts pressure on in the first half of play at Jack Trice Stadium on October 25, 2025, in Ames, Iowa. (Photo by David Purdy/Getty Images) | Getty Images

Week 6 betting lines are trickling out and BYU opened as a 14.5-point favorite over Iowa State prior to their game Friday night in Provo.

BYU is 4-0 after a 17-10 win over TCU. The Cyclones are 3-2 and picked up their first Big 12 win Saturday at home in a 45-42 shootout over West Virginia. Both teams rolled up over 500 yards of offense and Iowa State scored a TD in the final two minutes to come away with the win. Cyclone running back Aiden Flora rushed for 212 yards, 3 rushing touchdowns, and threw 2 touchdowns through the air.

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Iowa State was expected to be possibly the worst team in the Big 12, but the Cyclones have showed well in 5 games. They lost 31-17 at home to Utah and nearly pulled the upset in 16-13 road loss at Iowa. They had troubles slowing down Utah and West Virginia, but offensively Aiden Flora is a dangerous tailback. QB Jaylen Raynor has thrown 4 interceptions in his last three games, but completed 70% of his passes versus the Mountaineers and threw for 264 yards.

The game kicks off at 8:15 MT Friday night on ESPN, BYU’s first late-night game of the season. The health of starting running back LJ Martin will be a big storyline for the game.

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