Cardinals vs. Rams odds: Opening lines for Week 6 matchup

· Yahoo Sports

GLENDALE, ARIZONA - OCTOBER 11: Head coach Mike LaFleur of the Arizona Cardinals looks up at the scoreboard during the fourth quarter of the game against the Detroit Lions at State Farm Stadium on October 11, 2026 in Glendale, Arizona. Lions won 45-21. (Photo by Norm Hall/Getty Images) | Getty Images

No one expected the Arizona Cardinals at 1-4 to be favored in their week six matchup with the Los Angeles Rams.

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But I’m also not sure anyone expected at this point of the Mike LaFleur era that they would be the biggest underdogs of the NFL season by week six.

The largest spread of the season so far was the Cardinals +9.5 to the Los Angeles Chargers. We know how that one turned out, 

Yet, according to FanDuel Sportsbook the Arizona Cardinals opened as the largest underdogs of the season at +12.5-points ahead of their matchup with the Los Angeles Rams.

The craziest part… the Rams haven’t even played their week five game.

But, after the Arizona Cardinals beat down at the hands of the Detroit Lions, it’s hard to see anyone giving this team the benefit of the doubt until they actually do something on the field.

So, do you think the Cardinals can cover and is it fair that they are basically two touchdown underdogs?

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